Epigenome-Wide Association Study and Epigenetic Age Acceleration Associated with Cigarette Smoking among Costa Rican Adults
| dc.creator | Cárdenas, Andrés | |
| dc.creator | Ecker, Simone | |
| dc.creator | Fadadu, Raj P. | |
| dc.creator | Huen, Karen | |
| dc.creator | Orozco, Allan | |
| dc.creator | McEwen, Lisa M. | |
| dc.creator | Engelbrecht, Hannah Ruth | |
| dc.creator | Gladish, Nicole | |
| dc.creator | Kobor, Michael S. | |
| dc.creator | Rosero Bixby, Luis | |
| dc.creator | Dow, William H. | |
| dc.creator | Rehkopf, David H. | |
| dc.date.accessioned | 2024-08-14T15:31:06Z | |
| dc.date.available | 2024-08-14T15:31:06Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated smoking-associated DNAm signatures in the Costa Rican Study on Longevity and Healthy Aging (CRELES), including participants from the high longevity region of Nicoya. We measured genome-wide DNAm in leukocytes, tested Epigenetic Age Acceleration (EAA) from five clocks and estimates of telomere length (DNAmTL), and examined effect modification by the high longevity region. 489 participants had a mean (SD) age of 79.4 (10.8) years, and 18% were from Nicoya. Overall, 7.6% reported currently smoking, 35% were former smokers, and 57.4% never smoked. 46 CpGs and five regions (e.g. AHRR, SCARNA6/SNORD39, SNORA20, and F2RL3) were differentially methylated for current smokers. Former smokers had increased Horvath’s EAA (1.69-years; 95% CI 0.72, 2.67), Hannum’s EAA (0.77-years; 95% CI 0.01, 1.52), GrimAge (2.34-years; 95% CI1.66, 3.02), extrinsic EAA (1.27-years; 95% CI 0.34, 2.21), intrinsic EAA (1.03-years; 95% CI 0.12, 1.94) and shorter DNAmTL (− 0.04-kb; 95% CI − 0.08, − 0.01) relative to non-smokers. There was no evidence of effect modification among residents of Nicoya. Our findings recapitulate previously reported and novel smoking-associated DNAm changes in a Latino cohort. | en_CR |
| dc.description.pages | 1-13 | |
| dc.description.uri | https://www.nature.com/articles/s41598-022-08160-w | |
| dc.identifier.uri | https://repositorio.sibdi.ucr.ac.cr/handle/123456789/22490 | |
| dc.language.iso | en | en_CR |
| dc.publisher | Scientific Reports, Vol. 12 Núm | en_CR |
| dc.subject | EPIGENETIC | es_CR |
| dc.subject | SMOKING | es_CR |
| dc.subject | METILACION DE ADN | es_CR |
| dc.subject | MORTALITY | es_CR |
| dc.title | Epigenome-Wide Association Study and Epigenetic Age Acceleration Associated with Cigarette Smoking among Costa Rican Adults | en_CR |
| dc.type | Article |
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