Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies
| dc.creator | Cohorts Consortium of Latin America and the Caribbean (CC-LAC) | |
| dc.date.accessioned | 2024-08-13T21:32:24Z | |
| dc.date.available | 2024-08-13T21:32:24Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Background: Estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains un- known. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n = 168,287) and non-fatal (13 cohorts, n = 27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor. Results: Our RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 10 0,0 0 0 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana. Interpretation: RRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those esti- mated from cohorts in high-income countries. | en_CR |
| dc.description.pages | 1-12 | |
| dc.description.uri | https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(21)00064-8/fulltext | |
| dc.identifier.issn | 2667-193X | es_CR |
| dc.identifier.uri | https://repositorio.sibdi.ucr.ac.cr/handle/123456789/22486 | |
| dc.language.iso | eng | en_CR |
| dc.publisher | The Lancet Regional Health - Americas, vol.4 | en_CR |
| dc.subject | CARDIOVASCULAR DISEASES | es_CR |
| dc.subject | LATIN AMERICA | es_CR |
| dc.title | Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies | es_CR |
| dc.type | Article |
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