Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based study

dc.contributor.authorRehkopf, David H.
dc.contributor.authorDow, William H.
dc.contributor.authorRosero Bixby, Luis
dc.contributor.authorLin, Jue
dc.contributor.authorEpel, Elissa S.
dc.contributor.authorBlackburn, Elizabeth H.
dc.date.accessioned2021-11-22T17:26:56Z
dc.date.accessioned2022-03-18T03:45:06Z
dc.date.available2021-11-22T17:26:56Z
dc.date.available2022-03-18T03:45:06Z
dc.date.issued2013
dc.description.abstractStudies in humans suggest that leukocyte telomere length may act as a marker of biological aging. We investigated whether individuals in the Nicoya region of Costa Rica, known for exceptional longevity, had longer telomere length than those in other parts of the country. After controlling for age, age squared, rurality, rainy season and gender, mean leukocyte telomere length in Nicoya was substantially longer (81 base pairs, p<0.05) than in other areas of Costa Rica, providing evidence of a biological pathway to which this notable longevity may be related. This relationship remains unchanged (79 base pairs, p<0.05) after statistically controlling for nineteen potential biological, dietary and social and demographic mediators. Thus the difference in mean leukocyte telomere length that characterizes this unique region does not appear to be explainable by traditional behavioral and biological risk factors. More detailed examination of mean leukocyte telomere length by age shows that the regional telomere length difference declines at older ages.es_CR
dc.description.urihttps://sibdi.ucr.ac.cr/formularios/formulario-transferencia-ccp.php
dc.identifier.issn0531-5565
dc.identifier.urihttps://repositorio.sibdi.ucr.ac.cr/handle/123456789/17009
dc.language.isoenges_CR
dc.publisherExperimental Gerontology; Volumen 48, Número 11es_CR
dc.subjectBIOMARCADORESes_CR
dc.subjectLONGEVIDADes_CR
dc.subjectENVEJECIMIENTOes_CR
dc.subjectLEUCOCITOSes_CR
dc.subjectESTUDIOS DE CASOSes_CR
dc.titleLonger leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based studyes_CR
dc.typeArticlees_CR

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