Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction

dc.creator	Ruiz Narváez, Edward A.
dc.creator	Sacks, Frank M
dc.creator	Campos, Hannia
dc.date.accessioned	2025-05-28T16:01:59Z
dc.date.available	2025-05-28T16:01:59Z
dc.date.issued	2008
dc.description.abstract	The plasma concentration of apolipoprotein (apo) C-III is a strong predictor of the risk of coronary heart disease (CHD) (1, 2). Apo C-III impairs the clearance of apo B lipoproteins from plasma, which results in an increase in plasma triacylglycerol concentrations (3–7) and directly activates atherosclerotic and inflammatory pathways in vascular cells (8, 9). Therefore, genetic variation affecting the expression of the APOC3 gene may alter apo C-III metabolism and influence CHD. Minor alleles of the 3238C - G (SstI site), -482C-T, and -455T-C polymorphisms are associated with higher plasma triacylglycerol (10–13) and apo C-III (14) concentrations and with an increased risk of CHD (13, 15–17).	en_CR
dc.description.pages	1-8
dc.description.uri	https://sibdi.ucr.ac.cr/formularios/formulario-transferencia-ccp.php	es_CR
dc.identifier.issn	1938-3207
dc.identifier.uri	https://repositorio.sibdi.ucr.ac.cr/handle/123456789/24765
dc.language.iso	en	en_CR
dc.publisher	Am J Clin Nutr., no. 87
dc.subject	ENFERMEDADES CARDIOVASCULARES	es_CR
dc.subject	OBESIDAD	es_CR
dc.title	Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction	en_CR
dc.type	Article

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