Stressors over the life course and neuroendocrine system dysregulation in Costa Rica

dc.contributor.authorGersten, Omer
dc.contributor.authorRosero Bixby, Luis
dc.contributor.authorDow, William H.
dc.date.accessioned2021-11-24T13:21:17Z
dc.date.accessioned2022-03-18T01:52:31Z
dc.date.available2021-11-24T13:21:17Z
dc.date.available2022-03-18T01:52:31Z
dc.date.issued2010
dc.description.abstractObjectives: A key aspect of the increasingly popular allostatic load (AL) framework is that stressors experienced over the entire life course result in physiological dysregulation. Although core to AL theory, this idea has been little tested, and where it has been tested, the results have been mixed. Method: The study analyzes the Costa Rican Study on Longevity and Healthy Aging (CRELES), a new, cross-sectional, and nationally representative survey of older Costa Rican men and women (aged between 60 and 109 years). The survey period is between 2004 and 2006, and the survey has a sample size of 2,827 individuals. This article focuses on the relationship between a variety of stressors experienced over the life course and cortisol, dehydroepiandrosterone sulfate (DHEAS), epinephrine, and norepinephrine analyzed separately and in an index. Results: There are some links between certain stressors and worse cortisol levels, but overall, almost all of the stressors examined are not associated with riskier neuroendocrine biomarker profiles. Discussion: More work is needed, in order to establishthe connection between stressors experienced over the life course and resting levels of the neuroendocrine markers.es_CR
dc.description.urihttps://journals.sagepub.com/doi/full/10.1177/0898264310367516
dc.identifier.issn0898-2643
dc.identifier.urihttps://repositorio.sibdi.ucr.ac.cr/handle/123456789/17034
dc.language.isoenges_CR
dc.publisherJournal of Aging and Health XX(X)es_CR
dc.subjectBIOMARCADORESes_CR
dc.subjectHIDROCORTISONAes_CR
dc.subjectENVEJECIMIENTOes_CR
dc.titleStressors over the life course and neuroendocrine system dysregulation in Costa Ricaes_CR
dc.typeArticlees_CR

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