Fasting Whole Blood as a Biomarker of Essential Fatty Acid Intake in Epidemiologic Studies: Comparison with Adipose Tissue and Plasma

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dc.creatorBaylin, Ana
dc.creatorKyung Kim, Mi
dc.creatorDonovan Palmer, Amy
dc.creatorSiles Díaz, Xinia
dc.creatorDougherty, Lauren
dc.creatorTocco, Paula
dc.creatorCampos Núñez, Hannia
dc.date.accessioned2025-04-25T13:27:26Z
dc.date.available2025-04-25T13:27:26Z
dc.date.issued2005
dc.description.abstractBiomarkers could provide a more accurate measure of long-term intake than questionnaires. Adipose tissue is considered the best indicator of long-term essential fatty acid intake, but other tissues may prove equally valid. The authors evaluated the ability of fasting whole blood, relative to fasting plasma and adipose tissue, to reflect fatty acid intake. Costa Rican men (n = 99) and women (n = 101) completed a 135-item food frequency questionnaire and provided adipose tissue and blood samples from 1999 to 2001. Fatty acids were identified by using capillary gas chromatography. Correlation coefficients adjusted for age, sex, and body mass index were calculated. Diet-tissue correlation coefficients for α-linolenic acid and linoleic acid, respectively, were 0.38 and 0.43 in whole blood, 0.51 and 0.52 in adipose tissue, and 0.39 and 0.41 in plasma. High correlations were observed between whole-blood α-linolenic and linoleic acid and adipose tissue (r = 0.59 and r = 0.67) and plasma (r = 0.96 and r = 0.88), respectively. Results show that fasting whole blood is a suitable biomarker of long-term essential fatty acid intake, and its performance is comparable to that of fasting plasma. Thus, fasting whole blood could be the sample of choice in epidemiologic studies because of its ability to predict intake, its accessibility, and minimum sample processing.en_CR
dc.description.pages1-9
dc.description.urihttps://sibdi.ucr.ac.cr/formularios/formulario-transferencia-ccp.phpes_CR
dc.identifier.issn1476-6256es_CR
dc.identifier.urihttps://repositorio.sibdi.ucr.ac.cr/handle/123456789/24576
dc.language.isoenen_CR
dc.publisherAmerican Journal of Epidemiology, vol.162, no. 4en_CR
dc.subjectEPIDEMIOLOGIAes_CR
dc.subjectESTUDIOS EPIDEMIOLOGICOSes_CR
dc.subjectTEJIDO ADIPOSOes_CR
dc.subjectACIDOS GRASOSes_CR
dc.subjectSANGREes_CR
dc.subjectAYUNOes_CR
dc.titleFasting Whole Blood as a Biomarker of Essential Fatty Acid Intake in Epidemiologic Studies: Comparison with Adipose Tissue and Plasmaen_CR
dc.typeArticle

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