GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction
| dc.creator | Cornelis, Marilyn C. | |
| dc.creator | El-Sohemy, Ahmed | |
| dc.creator | Campos Núñez, Hannia | |
| dc.date.accessioned | 2025-04-25T15:41:58Z | |
| dc.date.available | 2025-04-25T15:41:58Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and DHA, has not been studied. The Δ6-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Δ6-desaturase gene (FADS2) may affect this conversion. Objectives: We hypothesize that high ALA is associated with a lower prevalence of the metabolic syndrome and that genetic variation in FADS2 modifies this association. Design: We studied 1815 Costa Rican adults. Adipose tissue ALA was used as a biomarker of intake, and metabolic syndrome was identified with the definition from the National Cholesterol Education Program, Adult Treatment Panel III. Prevalence ratios (PRs) and 95% CIs were estimated from binomial regression models, and the likelihood ratio was used to test for effect modification. Results: High concentrations of adipose tissue ALA were associated with lower PRs of the metabolic syndrome compared with low ALA (0.81; 95% CI: 0.66, 1.00, for the comparison between the highest and the lowest quintiles; P for trend < 0.02). Higher concentrations of adipose tissue ALA were associated with a lower PR among homozygote (0.67; 95% CI: 0.53, 0.86) and heterozygote (0.84; 95% CI: 0.72, 0.99) carriers of the FADS2 T allele, but not among homozygote carriers of the deletion variant allele (0.99; 95% CI: 0.78, 1.27; P for interaction: 0.08). Conclusions: Elevated ALA concentrations in adipose tissue are associated with lower prevalence of the metabolic syndrome. A lack of association among homozygote carriers of the FADS2 deletion allele suggests that this association may be due in part to the conversion of ALA into EPA. | en_CR |
| dc.description.pages | 1-7 | |
| dc.description.uri | https://sibdi.ucr.ac.cr/formularios/formulario-transferencia-ccp.php | es_CR |
| dc.identifier.issn | 0002-9165 | |
| dc.identifier.uri | https://repositorio.sibdi.ucr.ac.cr/handle/123456789/24581 | |
| dc.language.iso | en | en_CR |
| dc.publisher | The American Journal of Clinical Nutrition, Volumen 86, no. 3 | en_CR |
| dc.subject | ENFERMEDADES CARDIOVASCULARES | es_CR |
| dc.subject | DIETA | es_CR |
| dc.subject | GENETICA | es_CR |
| dc.subject | VEGETALES | es_CR |
| dc.title | GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction | en_CR |
| dc.type | Article |
Archivos
Bloque de licencias
1 - 1 de 1
No hay miniatura disponible
- Nombre:
- license.txt
- Tamaño:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descripción: