Association between hepatic lipase -514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference
| dc.creator | Baylin, Ana | |
| dc.creator | Ruiz Narváez, Edward A. | |
| dc.creator | Jensen, Majken K. | |
| dc.creator | Rimm, Eric B. | |
| dc.creator | Campos Núñez, Hannia | |
| dc.date.accessioned | 2025-05-29T16:33:34Z | |
| dc.date.available | 2025-05-29T16:33:34Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Background and aims: To examine whether the association between the 514 C/T polymorphism of the hepatic lipase gene and myocardial infarction (MI) is modified by history of hypercholesterolemia and increased waist circumference. Hepatic Lipase (HL) is a major determinant of HDL cholesterol, an established independent predictor of coronary heart disease (CHD) [1]. However, the role of HL in atherosclerosis remains uncertain. Overexpression of HL in transgenic and knockout animal models has resulted in both antiatherogenic and pro-atherogenic effects [2]. Although low HL activity in humans has been identified as a risk factor for CHD [3] the net effect of HL on CHD is hard to establish given its role in lipoprotein metabolism as both a lipolytic enzyme and as a ligand that facilitates uptake of lipoproteins [4]. Four linked polymorphisms (250 G to A, 514 C to T, 710 T to C, 763 A to G) have been identified in the promoter region of the HL gene [5]. These four poly- morphisms are in complete linkage disequilibrium and together define a common HL allele designed as 514 T allele. The T allele at position 514 of the HL gene is consistently associated with lower HL activity, higher HDL cholesterol, particularly HDL2 cholesterol, higher remnant-like particles, and triglyceride content and size of HDL and LDL particles [6]. Nevertheless, evidence of the effect of the 514 T allele on CHD is inconsistent. Some studies have shown no association [7-14], while others have shown an increased risk of CHD for carriers of the 514 T allele [15-19]. Surprisingly, the 514 T allele has not been inversely associated with CHD. | en_CR |
| dc.description.pages | 498-504 | |
| dc.description.uri | https://sibdi.ucr.ac.cr/formularios/formulario-transferencia-ccp.php | es_CR |
| dc.identifier.issn | 0939-4753 | |
| dc.identifier.uri | https://repositorio.sibdi.ucr.ac.cr/handle/123456789/24851 | |
| dc.language.iso | en | en_CR |
| dc.publisher | Nutrition, Metabolism and Cardiovascular Diseases, Volumen 20, no. 7 | |
| dc.subject | INFARTO MIOCARDIO | es_CR |
| dc.title | Association between hepatic lipase -514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference | en_CR |
| dc.type | Article |
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