Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption
| dc.creator | Cornelis, Marilyn C. | |
| dc.creator | El-Sohemy, Ahmed | |
| dc.creator | Campos Núñez, Hannia | |
| dc.date.accessioned | 2025-04-25T13:52:29Z | |
| dc.date.available | 2025-04-25T13:52:29Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | Background: Caffeine is the most widely consumed stimulant in the world, and individual differences in response to its stimulating effects may explain some of the variability in caffeine consumption within a population. Objective: We examined whether genetic variability in caffeine metabolism [cytochrome P450 1A2 (CYP1A2) −163A→C] or the main target of caffeine action in the nervous system [adenosine A2A receptor (ADORA2A) 1083C→T] is associated with habitual caffeine consumption. Design: Subjects (n = 2735) were participants from a study of gene-diet interactions and risk of myocardial infarction who did not have a history of hypertension. Genotype frequencies were examined among persons who were categorized according to their self-reported daily caffeine intake, as assessed with a validated food-frequency questionnaire. Results: The ADORA2A, but not the CYP1A2, genotype was associated with different amounts of caffeine intake. Compared with persons consuming <100 mg caffeine/d, the odds ratios for having the ADORA2A TT genotype were 0.74 (95% CI: 0.53, 1.03), 0.63 (95% CI: 0.48, 0.83), and 0.57 (95% CI: 0.42, 0.77) for those consuming 100–200, >200–400, and >400 mg caffeine/d, respectively. The association was more pronounced among current smokers than among nonsmokers (P for interaction = 0.07). Persons with the ADORA2A TT genotype also were significantly more likely to consume less caffeine (ie, <100 mg/d) than were carriers of the C allele [P = 0.011 (nonsmokers), P = 0.008 (smokers)]. Conclusion: Our findings show that the probability of having the ADORA2A 1083TT genotype decreases as habitual caffeine consumption increases. This observation provides a biologic basis for caffeine consumption behavior and suggests that persons with this genotype may be less vulnerable to caffeine dependence. | en_CR |
| dc.description.pages | 1-5 | |
| dc.description.uri | https://sibdi.ucr.ac.cr/formularios/formulario-transferencia-ccp.php | es_CR |
| dc.identifier.issn | 0002-9165 | |
| dc.identifier.uri | https://repositorio.sibdi.ucr.ac.cr/handle/123456789/24578 | |
| dc.language.iso | en | en_CR |
| dc.publisher | The American Journal of Clinical Nutrition, Volumen 86, no. 1 | en_CR |
| dc.subject | EPIDEMIOLOGIA | es_CR |
| dc.subject | CAFEINA | es_CR |
| dc.subject | DEPENDENCIA | es_CR |
| dc.title | Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption | en_CR |
| dc.type | Article |
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