6. Biblioteca del Centro Centroamericano de Población

El Centro Centroamericano de Población (CCP) es un centro de investigaciones de la Universidad de Costa Rica, establecido inicialmente en 1993 como un Programa adscrito a la Escuela de Estadística. El CCP tiene un área de acción multidisciplinaria en la investigación, capacitación y diseminación de información en población con un ámbito Centroamericano.

Noticias

Dirección: De la Fuente de la Hispanidad 100 este, 100 norte y 100 este.
San Pedro de Montes de Oca.
Centro Centroamericano de Población,
Universidad de Costa Rica
San José 2060, Costa Rica.

Correo electrónico: ccp@ucr.ac.cr

Teléfonos:
(506) 2511-1452,
(506) 2511-1450,
(506) 2511-1716 (Biblioteca)

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Mostrando 1 - 4 de 4

Adipose tissue biomakers of fatty acid intake
(American Journal of Clinical Nutrition, No.76, 2002) Baylin, Ana; Kabagambe, Edmond K.; Siles, Xinia; Campos, Hannia
The use of biomarkers to assess dietary intake has increased dramatically in the past few years (1-7). Biomarkers may provide a more accurate and objective measure of long-term intake than dietary questionnaires provide because biomarkers do not rely on memory, self-reported information, or interviewer bias. However, nutrient concentrations in tissue or blood do not always reflect dietary intake because they can be affected by genetic factors, smoking, obesity, physical activity, and metabolism.
Fasting Whole Blood as a Biomarker of Essential Fatty Acid Intake in Epidemiologic Studies: Comparison with Adipose Tissue and Plasma
(American Journal of Epidemiology, vol.162, no. 4, 2005) Baylin, Ana; Kyung Kim, Mi; Donovan Palmer, Amy; Siles Díaz, Xinia; Dougherty, Lauren; Tocco, Paula; Campos Núñez, Hannia
Biomarkers could provide a more accurate measure of long-term intake than questionnaires. Adipose tissue is considered the best indicator of long-term essential fatty acid intake, but other tissues may prove equally valid. The authors evaluated the ability of fasting whole blood, relative to fasting plasma and adipose tissue, to reflect fatty acid intake. Costa Rican men (n = 99) and women (n = 101) completed a 135-item food frequency questionnaire and provided adipose tissue and blood samples from 1999 to 2001. Fatty acids were identified by using capillary gas chromatography. Correlation coefficients adjusted for age, sex, and body mass index were calculated. Diet-tissue correlation coefficients for α-linolenic acid and linoleic acid, respectively, were 0.38 and 0.43 in whole blood, 0.51 and 0.52 in adipose tissue, and 0.39 and 0.41 in plasma. High correlations were observed between whole-blood α-linolenic and linoleic acid and adipose tissue (r = 0.59 and r = 0.67) and plasma (r = 0.96 and r = 0.88), respectively. Results show that fasting whole blood is a suitable biomarker of long-term essential fatty acid intake, and its performance is comparable to that of fasting plasma. Thus, fasting whole blood could be the sample of choice in epidemiologic studies because of its ability to predict intake, its accessibility, and minimum sample processing.
Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction
(Circulation, no. 118, 2008) Campos, Hannia; Baylin, Ana; Willett, Walter C.
Background—Intake of long-chain n-3 fatty acids found in fish is low in many countries worldwide. -Linolenic acid could be a viable cardioprotective alternative to these fatty acids in these countries. Methods and Results—Cases (n 1819) with a first nonfatal acute myocardial infarction and population-based controls (n1819) living in Costa Rica matched for age, sex, and area of residence were studied. Fatty acids were assessed by gas chromatography in adipose tissue samples and by a validated food frequency questionnaire specifically designed for this population. Odds ratios and 95% confidence intervals were calculated from multivariate conditional logistic regression models. Linolenic acid in adipose tissue ranged from 0.36% in the lowest decile to 1.04% in the highest decile. The corresponding median levels of intake were 0.42% and 0.86% energy. Greater -linolenic acid (assessed either in adipose or by questionnaire) was associated with lower risk of myocardial infarction. The odds ratios for nonfatal myocardial infarction for the highest compared with the lowest deciles were 0.41 (95% confidence interval, 0.25 to 0.67) for -linolenic acid in adipose tissue and 0.61 (95% confidence interval, 0.42 to 0.88) for dietary -linolenic acid. The relationship between -linolenic acid and myocardial infarction was nonlinear; risk did not decrease with intakes 0.65% energy (1.79 g/d). Fish or eicosapentaenoic acid and docosahexaenoic acid intake at the levels found in this population did not modify the observed association. Conclusions—Consumption of vegetable oils rich in -linolenic acid could confer important cardiovascular protection. The apparent protective effect of -linolenic acid is most evident among subjects with low intakes.
α-Linolenic acid, Δ6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction
(The American Journal of Clinical Nutrition, Volumen 85, no. 2, 2007) Baylin, Ana; Ruiz Narváez, Edward A.; Kraft, Peter; Campos Núñez, Hannia
Background:Δ6-Desaturase (FADS2) is the rate-limiting step in the polyunsaturated fatty acid (PUFA) biosynthetic pathway. Objective: The aim was to test whether the common deletion [T/-] in the promoter of FADS2 affects the PUFA biosynthetic pathway and consequently modifies the effect of α-linolenic acid (ALA) on myocardial infarction (MI). Design: Case subjects (n =1694) with a first nonfatal acute MI were matched by age, sex, and area of residence to 1694 population-based control subjects in Costa Rica. PUFAs were quantified by gas-liquid chromatography from plasma and adipose tissue samples. Least-squares means from generalized linear models and odds ratios (ORs) and 95% CIs from multiple conditional logistic regression models were estimated. Results: The prevalence of the variant T/- allele was 48%. Eicosapentaenoic acid, γ-linolenic acid, and arachidonic acid decreased in adipose tissue and plasma with increasing number of copies of the variant allele with a monotonic trend (P < 0.05 for all). Fasting plasma triacylglycerols by genotype were 2.08 mmol/L for TT, 2.16 mmol/L for T-, and 2.26 mmol/L for - - [ie, homozygous for the variant (deletion) allele] (P = 0.03). The FADS2 deletion was not associated with MI and did not significantly modify the association between adipose tissue ALA and the risk of MI. Conclusions: The FADS2 deletion may prevent the conversion of ALA into very-long-chain PUFAs. However, this metabolic effect is not translated into an attenuated risk between ALA and MI among carriers of the variant. It is possible that, at current intakes of ALA, any potential defect in the transcription of the gene is masked by the availability of substrate. Further research in populations deficient in ALA intake is warranted.

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Examinando 6. Biblioteca del Centro Centroamericano de Población por Materia "ACIDOS GRASOS"

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