Maestría Académica en Microbiología
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Examinando Maestría Académica en Microbiología por Autor "Arrieta Bolaños, Esteban Roberto"
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Ítem Estudio comparativo de frecuencias alélicas, genotípicas y haplotípicas de los genes de los antígenos leucocitarios humanos (HLA) en donantes de sangre de Costa Rica y construcción de un registro de datos moleculares para HLA(2010) Arrieta Bolaños, Esteban Roberto; Salazar Sánchez, LizbethThe Human Leukocyte Antigen (HLA) gene tic system is the most polymorphic in humans. lts most importan! function is to regulate the immune response by interacting with the T-cell receptor during the antigen presentation process. Its central role in the immune response and its extreme polymorphism make HLA most important in transplant therapy, and even more important with respect to haematopoietic stem cell transplantation. Consequently, typing of these antigens for compatibility studies has greatly developed in arder to cope with transplantation advances. Various molecular HLA typing methods are currently widespread. HLA allele and haplotype frequencies vary greatly among human populations and their description allows for the design of transplantation support resources like unrelated donar registries. These data are also interesting in terms of anthropology studies of the characterized population and also for biomedical research. These kind of studies have prompted the development of unrelated stem cell donar registries and cord blood banks, which help raising the probability of finding a compatible donar for a patient in need. Costa Rican stem cell transplantation programs desperately need the introduction of molecular HLA typing techniques. Also, a characterization of HLA allele and haplotype frequencies of this population, and the establishment of a national donar registry based on their molecular typing are needed. This study's aim is to study the allele, genotype and 2, 3 and 5 loci haplotype frequencies of HLA-A, HLA-B, HLA-Cw, HLA- DQBI and HLA-DRB 1,3,4,5 in the Costa Rica Central Valley Population (CCVP) using molecular typing of these genes in a sample of blood donors, with the compilation of the collected infonnation to create a molecular database on HLA Also, a comparison between HLA allele frequencies observed in the CCVP and those of other populations around the world was carried out. We anonymously and randomly obtained 130 samples...