Examinando por Autor "Yang, Yadong"
Mostrando 1 - 3 de 3
Resultados por página
Opciones de ordenación
Ítem APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica(Journal of Lipid Research, vol. 46, no. 12, 2005) Ruiz Narváez, Edward A.; Yang, Yadong; Nakanishi, Yukiko; Kirchdorfer, Jill; Campos, HanniaApolipoprotein C-III (apoC-III) and A-V (apoA-V) regulate triglyceride metabolism in opposite ways (1–3). In mice, the overexpression of the human APOC3 transgene (1) leads to severe hypertriglyceridemia, whereas knockout mice lacking the endogenous Apoc3 gene have hypotriglyceriemia (2). In contrast, overexpression of the human APOA5 transgene and the lack of the endogenous Apoa5 gene show opposite triglyceride effects (3). Several studies indicate that naturally occurring sequence variation in the APOC3 and APOA5 genes affects plasma triglyceride concentrations in humans (4–7). People with the G allele of the 3238C>G polymorphism (SstI site) in the 3 untranslated region (3 UTR) of APOC3 tend to have higher plasma triglyceride concentrations (4, 5), as do individuals with two minor alleles, 482C>T and 455T>C (8–10), found in the insulin response element (IRE) of the APOC3 promoter. Several minor alleles of APOA5, the 1131T>C (upstream of the proximal promoter) (3, 6, 7), c. 3A>G (in a putative Kozak sequence) (11), c.56C>G (amino acid change p.Ser19Trp in the signal peptide) (7, 11), IVS3 476G>A (3, 11), c.553G>T (amino acid change p.Gly185Cys in exon 3) (12), and c.1259T>C (located in the 3 UTR) (3, 11), are also associated with increased plasma triglyceride concentrations.Ítem Effect of apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica(Human Biology, Vol. 79, no. 6, 2007) Yang, Yadong; Ruiz Narváez, Edward A.; Kraft, Peter; Campos, HanniaApolipoprotein E (apoE) is a ligand for the low-density lipoprotein (LDL) receptor and the LDL receptor-related protein (LRP) (Mahley and Rall 2000). Through these receptors apoE mediates the uptake of chylomicron remnants into the liver and the uptake of circulating very low density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) particles into peripheral tissues and cells (Mahley and Rall 2000).Ítem Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica(Journal of Lipid Research, no. 45, 2004) Yang, Yadong; Ruiz Narváez, Edward A.; Niu, Tianhua; Xu, Xiping; Campos Núñez, HanniaTo assess common variants of the LPL gene that could influence susceptibility to myocardial infarction (MI), we assessed three functional single-nucleotide polymorphisms (SNPs), D9N, N291S, and S447X, in 1,321 survivors of a first acute MI and 1,321 population-based controls, matched for age, gender, and area of residence, all living in the Central Valley of Costa Rica. Conditional logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI). The frequency of the X447 mutant allele was significantly lower in cases than in controls (6.2% vs. 7.6%; P < 0.01), whereas no association with MI was found for D9N or N291S. The OR (95% CI) for carriers vs. noncarriers of the X447 allele was 0.80 (0.63–1.01); when considering the haplotype that contained X447 and normal alleles of D9N and N291S, the OR (95% CI) was 0.66 (0.48–0.91). Twelve other SNPs were assessed in a subgroup of the population, of which the four functional SNPs were found to be monomorphic, and no correlation with MI was observed for the other eight neutral SNPs. The X447 mutant allele of the LPL gene may protect from MI risk, although this effect is small.