Examinando por Autor "Campos, Hannia"
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Ítem Conjugated linoleic acid in adipose tissue and risk of myocardial infarction(The American Journal of Clinical Nutrition, 92:34-40, 2010) Smit. Liesbeth; Baylin, Ana; Campos, HanniaBackground: Despite the high saturated fat content of dairy products, no clear association between dairy product intake and risk of myocardial infarction (MI) has been observed. Dairy products are the main source of conjugated linoleic acid (CLA; 18:2n27t), which is produced by the ruminal biohydrogenation of grasses eaten by cows. Pasture-grazing dairy cows have more CLA in their milk than do grain-fed cows. Some animal models have reported beneficial effects of CLA on atherosclerosis.Ítem Decreased Consumption of Dried Mature Beans Is Positively Associated with Urbanization and Nonfatal Acute Myocardial Infarction(J Nutr, Vol. 135, no. 7, 2005) Kabagambe, Edmond K.; Baylin, Ana; Ruiz Narvaez, Edward; Siles, Xinia; Campos, HanniaLegumes may protect against myocardial infarction (MI). The objective of this study was to determine whether consumption of dried mature beans (referred to as beans), the main legume in Latin America, is associated with MI. The cases (n = 2119) were survivors of a first acute MI and were matched by age, sex, and area of residence to randomly selected population controls (n = 2119) in Costa Rica. Dietary intake was assessed with a validated FFQ. Of the population, 69% consumed 1 serving of beans/d (1 serving = one-third cup of cooked beans, 86 g). Consumption of 1 serving/d was significantly higher (P 0.001) in rural (81%) than in urban (65%) areas. Individuals who never eat dried beans or whose consumption was 1 time/mo were classified as nonconsumers. Compared with nonconsumers, intake of 1 serving of beans/d was inversely associated with MI in analyses adjusted for smoking, history of diabetes, history of hypertension, abdominal obesity, physical activity, income, intake of alcohol, total energy, saturated fat, trans fat, polyunsaturated fat, and cholesterol [odds ratio (OR) 0.62; 95% CI: 0.45–0.88]. No further protection was observed with increased number of servings/d (OR 0.73; 95% CI: 0.52–1.03 for 1 serving/d). In summary, we found that consumption of 1 serving of beans/d is associated with a 38% lower risk of MI. No additional protection was observed at intakes 1 serving/d. These findings are timely given the trend toward increased obesity, cardiovascular disease, and a reduction in the intake of beans in Latin American countries.Ítem Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction(Circulation, no. 118, 2008) Campos, Hannia; Baylin, Ana; Willett, Walter C.Background—Intake of long-chain n-3 fatty acids found in fish is low in many countries worldwide. -Linolenic acid could be a viable cardioprotective alternative to these fatty acids in these countries. Methods and Results—Cases (n 1819) with a first nonfatal acute myocardial infarction and population-based controls (n1819) living in Costa Rica matched for age, sex, and area of residence were studied. Fatty acids were assessed by gas chromatography in adipose tissue samples and by a validated food frequency questionnaire specifically designed for this population. Odds ratios and 95% confidence intervals were calculated from multivariate conditional logistic regression models. Linolenic acid in adipose tissue ranged from 0.36% in the lowest decile to 1.04% in the highest decile. The corresponding median levels of intake were 0.42% and 0.86% energy. Greater -linolenic acid (assessed either in adipose or by questionnaire) was associated with lower risk of myocardial infarction. The odds ratios for nonfatal myocardial infarction for the highest compared with the lowest deciles were 0.41 (95% confidence interval, 0.25 to 0.67) for -linolenic acid in adipose tissue and 0.61 (95% confidence interval, 0.42 to 0.88) for dietary -linolenic acid. The relationship between -linolenic acid and myocardial infarction was nonlinear; risk did not decrease with intakes 0.65% energy (1.79 g/d). Fish or eicosapentaenoic acid and docosahexaenoic acid intake at the levels found in this population did not modify the observed association. Conclusions—Consumption of vegetable oils rich in -linolenic acid could confer important cardiovascular protection. The apparent protective effect of -linolenic acid is most evident among subjects with low intakes.Ítem Nonfatal Acute Myocardial Infarction in Costa Rica: Modifiable Risk Factors, Population-Attributable Risks, and Adherence to Dietary Guidelines(Circulation Jourrnal of the American Heart Association, Volume 115, number 8, 2007) Kabagambe, Edmond K; Baylin, Ana; Campos, HanniaCardiovascular disease, including myocardial infarction (MI), is increasing in developing countries. Knowledge of risk factors and their impact on the population could offer insights into primary prevention. Methods and Results—We estimated the population-attributable risk (PAR) for major MI risk factors among Costa Ricans without a history of diabetes, hypertension, or regular use of medication (889 MI cases, 1167 population-based controls). Lifestyle and dietary variables were measured with validated questionnaires. In multivariate analyses, abdominal obesity (PAR, 29.3%), smoking (PAR, 25.6%), nonuse of alcohol (PAR, 14.8%), caffeine intake (PAR, 12.8%), physical inactivity (PAR, 9.6%), and poor diet (PAR, 6.0%) were the most important MI risk factors. Subjects in the favorable categories of the above 6 risk factors showed a lower risk of MI (odds ratio, 0.09; 95% CI, 0.03 to 0.33) than those in the unfavorable categories. Compared with women, men were more likely to smoke (31% versus 10%) but less likely to have waist circumferences greater than Adult Treatment Panel III cutoffs (9% versus 35%). Many subjects did not meet the American Heart Association or World Health Organization/Food and Agriculture Organization dietary guidelines. For instance, 95% obtained 7% of energy from saturated fat, 25% had 5% of energy from polyunsaturated fat, 63% had 1% energy from trans fat, and 53% had low fiber intake ( 25 g/d). Conclusions—These findings confirm the benefit of a healthy diet, physical activity, moderate alcohol, and cessation of smoking as approaches for the primary prevention of MI. Obesity and smoking were the 2 most important risk factors for nonfatal MI in Costa Rica.