Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region

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dc.contributor.authorMcEwen, Lisa M.
dc.contributor.authorMorin, Alexander M.
dc.contributor.authorEdgar, Rachel D.
dc.contributor.authorMacIsaac, Julia L.
dc.contributor.authorJones, Meaghan J.
dc.contributor.authorDow, William H.
dc.contributor.authorRosero Bixby, Luis
dc.contributor.authorKobor, Michael S.
dc.contributor.authorRehkopf, David H.
dc.date.accessioned2021-11-19T15:47:37Z
dc.date.accessioned2022-03-18T01:52:27Z
dc.date.available2021-11-19T15:47:37Z
dc.date.available2022-03-18T01:52:27Z
dc.date.issued2017
dc.description.abstractBackground: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population’s unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. Methods: In a cross-sectional subsample of the Costa Rican Longevity and Healthy Aging Study, we compared whole blood DNA methylation profiles of residents from Nicoya (n = 48) and non-Nicoya (other Costa Rican regions, n = 47) using the Infinium HumanMethylation450 microarray. Results: We observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, another hallmark of younger biological age. Conclusions: Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylationes_CR
dc.description.pages1-14es_CR
dc.description.urihttps://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-017-0128-2
dc.identifier.issn1756-8935
dc.identifier.urihttps://repositorio.sibdi.ucr.ac.cr/handle/123456789/16880
dc.language.isoenges_CR
dc.publisherEpigenetics & Chromatin,vol.10(21)es_CR
dc.subjectLONGEVIDADes_CR
dc.subjectBIODEMOGRAFIAes_CR
dc.subjectENVEJECIMIENTOes_CR
dc.subjectCOSTA RICAes_CR
dc.titleDifferential DNA methylation and lymphocyte proportions in a Costa Rican high longevity regiones_CR
dc.typeArticlees_CR

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Luis Rosero Bixby
Longevidad

SIBDI, UCR - San José, Costa Rica.

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