Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity

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dc.creatorDec, Eric
dc.creatorClement, James
dc.creatorCheng, Kaiyang
dc.creatorChurch, George M.
dc.creatorFossel, Michael B.
dc.creatorRehkopf, David H.
dc.creatorRosero Bixby, Luis
dc.creatorKobor, Michael S.
dc.creatorLin, David TS.
dc.creatorLu, Ake T.
dc.creatorFei, Zhe
dc.creatorGuo, Wei
dc.creatorChew, Yap Ching
dc.creatorYang, Xiaojing
dc.creatorDwi Putra, Sulistyo E.
dc.creatorReiner, Alex P.
dc.creatorCorrea, Adolfo
dc.creatorVilalta, Adrian
dc.creatorPirazzini, Chiara
dc.creatorPassarino, Giuseppe
dc.creatorMonti, Daniela
dc.creatorArosio, Beatrice
dc.creatorGaragnani, Paolo
dc.creatorFranceschi, Claudio
dc.creatorHorvath, Steve
dc.date.accessioned2024-08-14T16:28:56Z
dc.date.available2024-08-14T16:28:56Z
dc.date.issued2023
dc.description.abstractClaims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome- wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.en-CR
dc.description.pages1817-1835
dc.description.urihttps://link.springer.com/article/10.1007/s11357-023-00731-7
dc.identifier.issn2509-2723es_CR
dc.identifier.urihttps://repositorio.sibdi.ucr.ac.cr/handle/123456789/22494
dc.language.isoengen_CR
dc.publisherSPRINGER LINK, vol. 45
dc.subjectGENESes_CR
dc.subjectMORTALITYes_CR
dc.titleCentenarian clocks: epigenetic clocks for validating claims of exceptional longevityen_CR
dc.typeArticle

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